Manuso, a self-described “Euro mutt,” joined SuperGen Inc. as a director in 2001 and became chairman and CEO of Astex Pharma after SuperGen’s acquisition last summer of Astex Therapeutics Ltd. in the U.K. The 140-employee company has three cancer drugs in mid-stage clinical trials, but the FDA in March rejected expanding its blood cancer drug Dacogen to elderly patients with acute myeloid leukemia. Manuso’s eclectic career has taken him from counseling heroin addicts in Bedford-Stuyvesant, part of his domestic service as a conscientious objector during the Vietnam War, to buying, fixing up and selling Manhattan properties.
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